Endocrine Abstracts

Introduction: Antithyroid drugs (ATD) are usually the first-line treatment for Graves’ disease (GD). It represents an effective treatment with good compliance. This therapeutic modality can be the cause of adverse effects including hematological, cutaneous and hepatic complications. The aim of our study is to evaluate the efficacy of ATD as well as its tolerance in patients with GD.Methods: It is a retrospective study that included 76 patients, with...

Introduction: Hirsutism is defined as excessive pilosity development in women in androgen-dependent areas. It is the main revealing sign of hyperandrogenism. It is a frequent reason for consultation in Endocrinology.Methods: This is a retrospective study of 82 records of patients hospitalized for exploration of hirsutism in the endocrinology department of Farhat Hached Hospital in Sousse, over a period of 20 years from 1997 to 2017.<p class="abstext"...

Introduction: Hyperpigmentation is a clinical sign that can be associated with different endocrine disorders. It is commonly seen in Addison’s disease and has rarely been reported in Graves’ disease. The exact physio pathological mechanism of this sign is not well established in hyperthyroidism. We describe two cases of Graves’ disease accompanied by diffuse hyperpigmentation.Case report: Case 1 was a 63-year-old female ad...

Introduction: Biermer’s disease is a chronic inflammatory disease due to antibodies targeting parietal cells and intrinsic factor compromising vitamin B12 absorption leading to pernicious anemia, and gastric acid secretion leading to achlorhydria. Neuroendocrine tumors are rare neoplasms that have been reported during the evolution of chronic gastritis. We here describe a case of a type 1 gastric neuroendocrine tumor discovered alongside with Biermer’s disease.<p...

Background: Antithyroid drugs (ATD) are indicated as first intension in the treatment of Graves’disease (GD). Only two molecules are marketed in Tunisia: Benzylthiouracil (BTU) and Methimazole (MMI). There is still no clear conclusion about the choice of appropriate drug. Our objective was to compare the MMI treatment with the BTU in terms of efficacy and adverse effects (AEs).Methods: It’s a retrospective study. We studied patients with a firs...

Introduction: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders that result from the deficiency of one of several enzymes involved in the steroidogenic pathway for cortisol biosynthesis. The most common cause of CAH, accounting for 90% of cases, is 21-hydroxylase deficiency. The symptoms of disease very depending on the nature and severity of the enzyme deficiency as well as the sex of the individual. Non-classical CAH is generally late onset. Ho...

Introduction: Precocious puberty (PP) is the development of secondary sexual characteristics before the age of 8 years in girls and beforethe age of 9 years in boys. Central PP has an idiopathic origin in upto 95% of girls while in up to 50% of males. The diagnostic and the management of PP can beparticularly complex. Here we describe cases of two sisters having central PP with different presentation and evolution.Observations: First case: A 13-years-old...

Background: Medullary thyroid carcinoma (MTC) is a rare neuroendocine tumor that that may be associated with paraneoplastic ACTH-dependent cushing syndrome. There are few case reports on the coexistence of medullary thyroid carcinoma and adrenal adenoma with ACTH-independent Cushing syndrome.Case presentation: We report the case of a 42-year-old woman, with no family history of endocrine malignancy or endocrine disorders. She underwent total thyroidectom...

Background: Hajj is one of the five pillars of Islam and is a must–do for all adult Muslims once in their life provided they are able to do it. It’s estimated that pilgrims with diabetes could exceed 220000/year. Patients with diabetes are at a great risk of illness due to the nature of the disease and the altered daily routine (overcrowding, inadequate nutrition, poor access to drinking water, hot weather and physical exertion).The primary aim of this study is to ...

IntroductionGrave’s disease is an autoimmune thyroid disorder. It is the most frequent cause of hyperthyroidism with variable manifestations. When not recognized in time and not adequately treated, Graves’ disease poses serious risks and can have severe complications.ObservationA 63-year-old female was admitted to the endocrinology department for severe thyrotoxicosis. She was diagnosed in 2011 with...